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Different indication : Afamelanotide is approved for EPP

TRPA1 and TRPM8, but also the heat-sensitive TRPV1 and more recently, TRPV4, have also been found to be involved in paclitaxel-, vincristine- and thalidomide-induced neuropathy, where both increased channel expression and analgesic effects from antagonists were reported (Materazzi et al., 2012

These features, while concerning in acquired nevi within adults, are an expected finding in congenital nevi, and they are more prominent in lesions biopsied in infants

Targeted therapies such as oncolytic herpes simplex virus have shown promise in preclinical models of MPNSTs

Physiol.,292: R1836 41