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A subset of immune cells, including macrophages, neutrophils, T cells, and B cells, have been implicated in ferroptosis or are intrinsically sensitive to ferroptosis due to changes in gene expression during maturation, which can significantly affect both innate and adaptive immunity, as recently reviewed in detail by Chen et al

Y., Herman, A

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However, its successful application will require further elucidation of TREM biology in humans, regarding the cell-type specificity of TREM expression (e.g., in astrocytes, oligodendrocytes, and neurons), species differences between humans and mice, immature metabolic and mitochondrial features of in vitro culture (e.g., BV and iPSC-derived cells), early-onset or late-onset, and the temporal dynamics of disease progression with senescence

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