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Devices such as the xCELLigence System [40] and the wMicroTracker System [24, 37] have been validated for high-throughput drug screening with Caenorhabditis elegans and a few parasitic helminth species, yet the readout is limited entirely to locomotion activity

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The role of leucine in the human body is associated with the absence of the branched-chain aminotransferase enzyme in the liver, which results in the large supply of branched-chain amino acids appearing in the muscle (106)

Despite its curative potential, HSCT is reserved for the most severe and refractory cases, as it carries significant risks