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One hypothesis from researchers at Harvard Medical School: chronic NNMT suppression might alter methylation donor availability, since NNMT consumes S-adenosylmethionine (SAM) as a methyl donor

It can affect your bodys response to insulin and insulin-releasing medications, so your doctor may need to adjust your dosages of these medications to reduce the risk of hypoglycemia (low blood sugar)

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Just remember to use them responsibly and in conjunction with other hangover remedies like hydration and rest