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This absence of foundational pharmacokinetic information constitutes a major knowledge gap with direct implications for clinical application, dosing strategies, and safety monitoring

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Concentration (mg/mL) 0 10 20 40 50 60 80 100 Average OD 0.068 0.109 0.151 0.232 0.274 0.316 0.400 0.482 Absoluted OD 0 0.041 0.083 0.164 0.206 0.248 0.332 0.414

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