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For example, prior studies have identified that urine from IC/BPS patients experiencing pain and low bladder capacity have a significantly increased abundance of active neutrophil elastase 23 , a serine protease with relatively broad substrate specificity 59

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4.2 Prebiotics as critical modulators of gut-thyroid homeostasis Prebiotics, indigestible dietary fibers that selectively stimulate the growth and activity of beneficial gut bacteria, serve as essential adjuncts to probiotic therapy and independently contribute to hypothyroidism management (Ouyang et al., 2024)

Heres an example from the fNCI report for Olivia Seitz, a former figure skater who suffered for over a decade before getting treatment: Olivia's explanation of the findings: The fNCI showed that my thalamus was hypoactive and my basal ganglia was completely out to lunch