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Moreover, under the pathological conditions of PD, immune cell Toll-like receptor TLR4/2 can be activated by intestinal microbial metabolites, intensifying neuroinflammation

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Neurotrophic factors like glial cell-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) have emerged as possible agents to promote dopaminergic neuron survival and function in preclinical PD models (52)

In particular, it has been demonstrated that Zn stimulates oligomerization of higher molecular weight forms of adiponectin through modulation of disulfide bond formation [85]

To achieve this, we attempted to co-synthesize NS1 alone alongside a polyprotein containing NS2A to NS5 (NS2A-5) in a single cell-free reaction by mixing their respective mRNAs 38