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The mutations of IDH1 or IDH2 exhibit a neomorphic activity by converting glutaminederived KG to 2hydroxyglutarate (2HG), which competitively inhibits KGdependent histone and DNA demethylases (Dang et al , 2010

Recently, another selective inhibitor of GLS1, CB-839 (telaglenastat), showed no significant side effects in preclinical trials and is currently undergoing full clinical trials 45

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Most pigmentation responds well to a combination of prescription topicals, medical chemical peels, and lasers
