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doi: 10.1038/361031a0

Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice

Toxins interfere with proper thyroid function, as explained in the Environmental Protection Agencys (EPAs) article, What is Endocrine Disruption? The effects of endocrine (including thyroid) disruption include: Developmental malformations Interference with reproduction Increased cancer risk Disturbances in the immune and nervous system function These disruptions are caused by a number of manufactured and naturally occurring chemicals, including organochlorine compounds, ethane (DDT) and its metabolite DDE, and polychlorinated biphenyls (PCBs)