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However, in many cases peripheral symptoms, such as muscle fatigue, either prevail or are an important part of the clinical presentation

doi: 10.1038/s41598-022-10481-9

Particularly, we highlight progress made towards understanding the translocation of Lipid II across the cytoplasmic membrane by the MurJ flippase, as well as the recent discovery of a novel class of PG polymerases, the SEDS (shape, elongation, division and sporulation) glycosyltransferases RodA and FtsW

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Together with other mediators, PDGF in turn promotes the metabolic effects of TGF up-regulation, activity of myofibroblasts, and recruitment of fibrotic cells, enhancing the ECM deposition and fibrotic plaque formation (Lucattelli et al., 2008)