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Eric Topol of Scripps Research Translational Institute was more direct: "These peptides have no data to support their safety and efficacy." The clinical proponents argue that the FDA's safety concerns immunogenicity risk, impurity risk, organ toxicity are theoretically valid but speculative in practice
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The peptide backbone becomes chemically unstable above refrigeration temperatures, which can reduce bioavailability and diminish the medication's intended metabolic effects
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