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Its the difference between clean data and a confounded experiment

In fibrotic tissues, the level of PAI-1 is elevated, contributing to excessive accumulation of collagen and other ECM proteins in the wound area, preventing tissue proteolytic activities and thus preserving scarring [50]

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Immunogenicity: No Antibody Formation A critical safety consideration for any peptide therapy is immunogenicity, the potential to trigger immune system responses that could lead to allergic reactions, reduced efficacy through antibody neutralization, or autoimmune complications

von Eckardstein et al, 1994)