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Description
The major pathologic manifestationschronic hemolysis, microvascular occlusions, and tissue damageall stem from the tendency of HbS molecules to stack into polymers when deoxygenated

These molecules damage cell membranes via peroxidation and DNA via oxidation

Silicosis: An Update and Guide for Clinicians

Mori, Q

Soc, 2006, 128, 49544955
