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The pathogenesis of homocysteinemia: interruption of the coordinate regulation by S-adenosylmethionine of the remethylation and transsulfuration of homocysteine
doi: 10.1007/s12035-016-0079-9
Trial averages at the highest dose (12 mg) reached around 24% body weight loss at 48 weeks, and around 28% at 68 weeks in the obesity plus knee osteoarthritis trial
doi: 10.1371/journal.pone.0063983
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