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Mild cognitive impairment: diagnosis and subtypes

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2013;17(Suppl 1):S367-S373

In this process, accumulation of lipid bilayer peroxides (PLOOHs) irreversibly triggers ferroptosis when it exceeds the antioxidant capacity of the cell ( Ipla2 is an enzyme capable of hydrolyzing lipid peroxidation, which hydrolyzes oxidized PUFA-PLs from the phospholipid molecules of the cell membrane and reduces the accumulation of lipid peroxidation, thus inhibiting ferroptosis to a certain extent ( Antioxidant defenses The Xc-system consists of two subunits, SLC7A11 and SLC3A2

doi: 10.1002/anie.202218407 123 TangZLiuYHeMBuW