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Consequently, changes in GSH levels after administration of intoxicating doses of EtOH will likely represent the combined effects of both EtOH and food deprivation
Thus, regular alcohol consumption can increase P450 2E1 activity, setting the stage under certain circumstances for increased acetaminophen metabolism through this pathway
The assay was initially reported in the 1970 s (Gupta 1973), although an earlier Japanese paper mentions its potential (Otomo 1965)
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