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Thus, immune cells may be more likely to generate heteromeric complexes between dopamine receptors and cytokine or chemokine receptors that enable dopamine to influence immune activity

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Reactive astrocytes acquire heterogeneous characteristics that can contribute to brain disorders via the non-cell-autonomous mechanisms

112,113 A single dose of CTX310 in non-human primates resulted in 70% mean editing of ANGPTL3 in the liver, an over 85% reduction in plasma ANGPTL3 protein, and a 60% reduction in TG, with effects lasting beyond a year and only transient liver enzyme elevation