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The small intestine and large intestine (especially the colon) are now recognised to be vastly different anatomically, in terms of physiological functions, pH, and number of bacteria [64]
doi: 10.5501/wjv.v10.i2.34
3 Gut microbiota in health and disease The adult human gut is colonized by a variety of more than 1000 species of microorganisms, reaching numbers up to 10 14 [44]
These changes support the massive clonal expansion of pathogen-specific T cells and their differentiation into effector cell subsets, where they function as protein production factories for effector molecules, including inflammatory cytokines and cytolytic granzymes
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