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Distribution of estrogen receptors in various cell types of normal, hyperplastic, and neoplastic human endometrial tissues

doi: 10.1126/science.aad8588

Future studies on the biochemical and chemical basis underlying the effects of Chinese Yang/Qi-invigorating tonic botanical drugs/herbal formulations from a mitochondrial perspective will hopefully provide novel insights into the rational development of new drugs for the prevention and/or treatment of CKD

Additionally, macrophages exhibit synergistic characteristics of dynamic phenotypic conversion and functional remodeling in response to DAMPs: during the acute injury phase, DAMPs (such as high-mobility group box protein B1 and adenosine triphosphate) activate the Toll-like receptor 4/P2X7 receptor pathway, which in turn activates the NF-B and NLRP3 inflammasome, driving macrophages toward M1 polarization and the secretion of pro-inflammatory factors such as interleukin-1(IL-1) and tumor necrosis factor- (TNF-), thereby establishing an efficient pathogen clearance mechanism (Gong et al., 2020) (193)

[DOI] [PubMed] [Google Scholar] 355.Belderbos M.E., Houben M.L., Wilbrink B., Lentjes E., Bloemen E.M., Kimpen J.L.L., Rovers M., Bont L