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Huang, T., et al
Key considerations: Limited long-term human safety data While copper is an essential micronutrient for the body, too much copper can be dangerous
Inhibition of cyclic guanosine monophosphate accumulation in response to S-nitroso-L-cysteine and sodium nitroprusside by methylene blue was completely prevented by superoxide dismutase but not catalase
As of January 2015, there were over 60 US FDA-approved peptide medications, 140 peptide drugs being evaluated in clinical trials, and 500 in pre- clinical development
Other anti-depressants including ketamine may also function in part through inhibition of nNOS (Shen et al., 2022)
