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This receptor is expressed not only in neurons and astrocytes but also in microglia, and preclinical studies have demonstrated that A 2A receptor antagonists exert robust neuroprotective effects across multiple animal models of neurodegeneration, including both AD and PD [474478]

The activation of receptors localized in the somatodendritic compartment decrease excitability, whereas terminally localized receptors inhibit transmitter release

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However, weight-loss results may take about 30 days to become visible, especially when combined with a healthy diet and regular exercise

This subject clearly requires considerable additional research, but is outside the focus on presynaptic receptors in the present review article