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doi: 10.1101/gad.17420111 84 WuYJiaCLiuWZhanWChenYLuJet al
We further identified the glutamine and alanine (the top two amino acids increased in serum from GCGR-KO mice) as inducers of cell VGF upregulation (Fig
In summary, these data show that BH3 mimetics are substrates of ABCC1 and that overexpression of ABCC1 limits the sensitivity of AML cells to BCL-2 inhibitors by reducing their intracellular concentration
| Hussain, SP., et al
