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In brief, HUVECs were lysed in the Co-IP buffer containing 20 mM Tris-HCl (pH7.5), 100 mM NaCl, 0.5 mM EDTA, 0.5% NP-40, 0.5 mM PMSF, 0.5% protease inhibitor cocktail on ice for 20 min

B12 reduces circulating levels of homocysteine, a compound linked to increased risk of heart attack and stroke

In conclusion, ultra-high-dose methylcobalamin was not found to be significantly superior to placebo

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For visible skin benefits, both supplements typically require regular use over several weeks