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As for palmitoylation, palmitoyl acyltransferases (PATs) regulate synaptic connections

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While epidemiological evidence indicates that this motor system disease is associated with poisoning from cyanogenic glucosides found in improperly processed cassava, not all individuals who rely on a cyanogenic diet are affected during outbreaks of konzo, suggesting additional and yet unknown factors required for onset of disease 4,5

Semaglutide is FDA-approved under two brand names: Ozempic (approved 2017 for type 2 diabetes at doses up to 1 mg weekly) and Wegovy (approved 2021 for chronic weight management at doses up to 2.4 mg weekly)