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The kynurenine pathway is linked to inflammation in MDD through the action of kynurenines, metabolites of the kynurenine pathway that present neurotoxicity when released in an exacerbated manner, in addition to reducing serotonin synthesis

Honokiol restores microglial phagocytosis by reversing metabolic reprogramming

The damage associated with long-term exposure to UV light and cellular oxidative stress is more severe, like photoageing and the risk of cancer
Poor sleep impairs tissue repair, elevates inflammatory markers, and lowers pain tolerance all of which directly impact foot and ankle conditions
