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This chronic state of cellular hypoxia (a severe lack of oxygen at the tissue level) is now believed to be a primary physiological driver of the profound physical exhaustion, heavy limbs, and debilitating post-exertional malaise (PEM) that patients experience

Nootropic drugs in Alzheimer disease treatment

[PubMed: 15645308] 232

Besides iron and ROS, ferroptosis is regulated by other pathways such as the p53 pathway in cancer, it can be suppressed by several pathways including ferroptosis suppressor protein 1 (FSP1)-CoQ10 pathway [6, 7], GCH1-BH4 pathway [8], and the DHODH-CoQH2 system [9, 10] (Fig

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