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NNMT inhibitors are selective and do not impact related methyltransferases or enzymes in the NAD + salvage pathway The selectivity of NNMT inhibitors was confirmed by testing against a panel of structurally similar methyltransferases and two enzymes in the NAD + salvage pathway (NAMPT and SIRT1
Bishop JB, Phillips LG, Mustoe TA, et al
An IPGTT on 14-week-old NOD mice revealed that MOTS-c, exendin-4 and combined treatment significantly improved glucose tolerance (Fig
Tian, T
[DOI] [PMC free article] [PubMed] [Google Scholar] 73.Miguel G.A., lvarez-Lpez C
