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hence, this compound has been initially studied as a drug therapy against certain types of cancers, such as T-cell leukemia and lymphoma 238,239

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Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature Medicine , 20(4), 398-403

This loop is the storage mechanism for B12 in normal mammals as the intrinsic factor from the stomach holds onto the B12 and saves it for the ilium to recover and send to the liver