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The authors reported an increased Firmicutes/Bacteroidetes ratio and Streptococcus abundance, with a reduction in Prevotella strains in patients with active MS when compared with healthy controls and patients with MS in remission ( Prevotella strains was inversely associated with Th17 cells in the small intestine, while positively related to disease activity ( 2.4.3 Treatment strategies 2.4.3.1 Probiotics Synergistic therapeutic effects may be exerted by the different strains in probiotic cocktails

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Consistent with abnormal insulin function, upon NFS1 inhibition we observed elevated fasting blood glucose levels (Fig