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PubMed Chang CH, Tsai WC, Lin MS, et al

This has led to widespread abandonment by the pharmaceutical industry of research and development for CNS disorders, despite increased diagnoses of neurodegenerative disorders and the continued lack of adequate treatment options for brain injuries, stroke, neurodevelopmental disorders, and neuropsychiatric illness

& Slutsky, A

Two of these case series suggest that dosage may be of importance, with individual differences and higher doses more effective than lower ones where dose was titrated up (dosage ranges 6001800 mg per day)
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Aldred J, et al