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Genetic restoration of Cav1 expression in Egln1Tie2Cre mice normalizes nitrative stress, reduces pulmonary hypertension, and improves right heart function [117]
The androgen signature is enhanced by the insulin outputs obtained through the PI3K-AKT-mTOR pathway, and in turn, the symptoms are amplified
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doi: 10.1016/0300-483X(93)90213-C 57
Childs BG, Durik M, Baker DJ, van Deursen JM (2015) Cellular senescence in aging and age-related disease: from mechanisms to therapy
