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Journal of the American Chemical Society, 131(42), 15078-15079

Some people may struggle to absorb enough through food or supplements, making injections a helpful option

However, they're relatively rare

When to Expect Knots After Spider Vein Treatments In general, you can expect knots to appear at injection sites within a few days to 2 weeks after spider vein treatments: Immediately after treatment: Some patients experience bruising, swelling, and very mild lumps immediately or within a day or two of procedures like sclerotherapy

(Side Effects & Risks) AOD-9604 is generally considered safe and well-tolerated, but like any peptide, it comes with potential side effects and risks