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The antimalarial drug chloroquine, known since 1934, is able to increase the pH of cellular compartments

10.1097/QCO.0000000000000718 84

Anti-inflammatory agent 107 reduces levels of inflammatory biomarkers ( TNF- , IL-6 , INF- , NF- , C-reactive protein and Erythrocyte Sedimentation Rate) and enhances the endogenous antioxidant defense system by elevating SOD (Superoxide Dismutase), CAT (Catalase) and GSH ( Glutathione ) activities

46 47 48 49,50 Critical Analysis of the Evidence Despite the valuable information provided by the current review, it is necessary to consider the variability and limitations of the scientific evidence supporting the use of supplements to treat and manage PCOS

In chronic wounds, the pathological microenvironment typically presents with acidic pH, elevated enzymes, ROS overproduction, and bacterial biofilms that hinder healing