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Intramuscular administration remains the gold standard for these conditions, as recommended by NICE and the British Society for Haematology

This may be important since without therapy, the occluded superior sagittal sinus rapidly provoked a particular syndrome, the severe brain disturbances, brain swelling and lesions (i.e., confluent infarction encompassing most of the cerebral cortex) and highly increased positive pressure values and thrombosis in the superior sagittal sinus

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In contrast, the injection of GSH itself (100 mol/kg, IV), while having positive effects on breathing did not attenuate the negative effects of this dose of fentanyl on breathing parameters

Formyl peptide receptor 1 (FPR1) mediates these effects