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The inhibition of SIRT3 leads to the downregulation of superoxide dismutase 2 (SOD2) expression, resulting in increased levels of ROS and subsequent mitochondrial dysfunction

Acetyl-L-carnitine (ALC) is a form of L-carnitine, an amino acid that is found in nearly all cells of the body

(Fig.4, Fig 5) Discussion With this study, the Neuropathic Pain Interest Group of the Italian Society of Neurology aimed to provide neurologists with practical guidelines for the treatment of fibromyalgia, a condition in which the involvement of the peripheral and central nervous system has been confirmed in several studies [2]

Exercising regularly and quitting smoking can help a lot

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