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In the central nervous system, mast cell mediators can cross the blood-brain barrier, activating microglial cells and driving the severe neuroinflammation responsible for profound cognitive impairment and brain fog

Nat Cell Biol 22(10):12761285 Ruan X et al (2024) Breast cancer cell-secreted miR-199b-5p hijacks neurometabolic coupling to promote brain metastasis

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Among these, thymosin beta-4 (TB-4) and its shorter synthetic fragment TB-500 are increasingly central to regenerative biology research
