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The potential for intravenous ascorbic acid as an adjunct to cancer therapies is currently under investigation in phase II clinical trials

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In medical settings it is usually diluted in normal saline and infused slowly into a vein, with a typical loading dose of 50 mg per kilogram over two to three minutes followed by maintenance doses every six hours or by continuous infusion

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In research and some specialty settings, intestinal permeability can be assessed with methods such as orally ingested sugar probes like lactulose and mannitol, while some endoscopic or biopsy-based techniques are used more selectively

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