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It is produced in the photosynthesizing cells at the level of chloroplasts and peroxisomes, the latter being the major site of intracellular H 2 O 2 production [5], during the photosynthetic carbon oxidation cycle and, to a lesser extent, during photorespiration, and also in the mitochondria, during the respiratory electron transport chain [2]

MT: Writing original draft

Anti-inflammatory effects The principle mechanisms through which butyrate exerts its anti-inflammatory effects are the suppression of nuclear factor B (NFkB) activation, the inhibition of interferon production and the upregulation of peroxisome proliferator-activated receptor (PPAR), which may result from the inhibition of HDAC [21]

In addition, the dataset generated and analyzed during this study, which contributed to the article, can be made available by the corresponding authors (K.B

[DOI] [PubMed] [Google Scholar] Draper A