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When the CCL is left as the primary defense against shearing forces without the support of strong leg muscles, it is subjected to increased stress and strain

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Ito et al., 2023) (this may be particularly relevant for the destabilization of myelin), synaptic dysfunction (Tu et al., 2014) (this includes impairment of signaling at the axo-myelinic synapse, crucial for survival of the myelinated axon