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Further supporting this notion of the bidirectional relationship between age and sleep-wake disruption, studies have noted that behavioral or genetic manipulation of circadian rhythms also causes aging-like phenotypes (Hood and Amir, 2017)

incubations with kidney and colon homogenates could slowly metabolize LDX over time

2021;2021 doi: 10.1155/2021/6619515

a critical review

Aging gut microbiota at the cross-road between nutrition, physical frailty, and sarcopenia: is there a gutmuscle axis
