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Given the many unknowns with high dose folic acid supplementation, particularly unmetabolized folic acid (as covered in my folate article), Im not able to draw any strong conclusions here

heres the general approach

Hoey H, Linnell JC, Oberholzer VG, Laurance BM

Because it bypasses digestion, the nutrients enter the bloodstream directly, leading to more efficient nutrient utilization

Animal data: strong In obese mouse models, AOD-9604 consistently reduced body weight and increased fat oxidation over 14 days of treatment
