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1d), we did not observe differences at the protein level as assessed by immunofluorescence (Fig

No significant sex-dependent differences in mean activity values were found, but the degree of variation was greater in microsomes from females (7.4-fold) than in males (4.1-fold)

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Furthermore, IFN- activates ACSL4, enabling the integration of arachidonic acid into phospholipids and thereby enhancing oxidative susceptibility (55, 56)

each case is judged individually.11 Solid evidence on the safety of parenteral, lifelong, high dose hydroxocobalamin is available from decades of treating patients with inborn errors of B 12 metabolism (eg, cobalamin C deficiency).6768 Symptom monitoring Monitor symptoms regularly (eg, every two to three months) as they may reappear, even after several months, if injection frequency is reduced