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Studies have confirmed that 25-hydroxycholesterol (25-OHC) promotes glial ferroptosis and lipid peroxidation, thereby contributing to ALS progression

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However, lysosomal dysfunction compromises this clearance mechanism, leading to intraneuronal build-up and aggregation of -synuclein 49
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The newly formed membrane compartments fuse at their edges to form a double membrane vesicular structure called the autophagosome
