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5-Amino 1MQ Designed to block an enzyme called NNMT, which is present in cellular aging and fat

10.1038/sj.emboj.7601253 EMBO J

AOD 9604 works by stimulating lipolysis (fat breakdown) and inhibiting lipogenesis (fat formation)

Using multiple reaction monitoring (MRM) positive ion mode, the 1-MNA NNMT reaction product was quantified from peak area ratios using AB Sciex Analyst and MultiQuant 2.1 software and the parent precursor and Q3 masses set to m/z 137.1 and 94.1, respectively
Studies show that oligomenorrhoeic PMOS patients have elevated kisspeptin pulse frequency but a broken temporal coupling between kisspeptin and LH pulses meaning kisspeptin is firing, but it is not translating into coordinated ovulatory signalling
