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Nitric oxide functions as an important messenger molecule involved in cellular communication and vascular regulation

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Current pharmacological strategies for UC primarily include 5-aminosalicylic acid (5-ASA), glucocorticoids, thiopurines, biological medications, and anti-cytokine therapies (Lamb et al., 2019

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Aside from cleavage, upregulated enzymes can also be used to activate aPS via conformational changes