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Mattick JS, Makunin I V

It inhibits the thioredoxin-interacting protein (TXNIP), a key regulator of ROS production, which in turn downregulates the NLRP3 inflammasome, reducing inflammation and oxidative stress-induced tissue damage

First, puerarin undergoes glucuronidation catalyzed by UGTA1 (UDP-glucuronosyltransferase 1A1: Gene ID 54658) to produce puerarin-7-O-glucuronide, or it undergoes hydrolysis to produce daidzein (Luo et al., 2012)

Individuals affected by the rare disease known as ryanodine receptor 1-related myopathies (RYR1-RM) present genetic mutations in the RYR1 gene, which plays a crucial role as the main calcium channel in skeletal muscle

"Depression among adults with neurofibromatosis type 1: prevalence and impact on quality of life"