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Potency values (EC 50 ) for bremelanotide were reported by Palatin on hMC1R (EC 50 = 0.095 nM), hMC3R (EC 50 = 2.4 nM), and hMC4R (EC 50 = 4.07 nM) in cAMP assays ( 50 = 5.5 nM, E max = 92%) compared to hMC4R (EC 50 = 0.22 nM, E max = 99%) ( Table 3 ) ( Table 3 Potency values and nonclinical highlights of melanocortin agonists in development
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