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The terminal carboxylic groups of PLGA chains impart its surface negatively charged, which can be modified through functionalization to facilitate targeted drug delivery 110

doi: 10.1096/fasebj.12.6.479

Front Pharmacol 5:151 Stamler JS, Simon DI, Osborne JA, Mullins ME, Jaraki O, Michel T, Singel DJ, Loscalzo J (1992) S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds

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50 Moreover, probiotics exhibit direct, strain-specific antioxidant properties through various mechanisms, which have been extensively reviewed in recent literature