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Several hypotheses are proposed that explain this GSSG accumulation

Water retention is risky, as it contributes to major discomfort with mobility and is associated with serious health conditions such as cardiovascular failure, malignant lymphedema, or kidney disease

In this case, the enzyme -glutamylcyclotransferase catalyzes the conversion of -glutamyl-L-cysteine to 5-oxoproline, favoring the occurrence of 5-oxoprolinuria, chronic metabolic acidosis and neurological disorders (Figure 2) [22]

Helps in giving higher-level fitness performance

[DOI] [PubMed] [Google Scholar] Iwanaga M, Mori K, Iida T, Urata Y, Matsuo T, Wasunaga A, Shibata S, Kondo T