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As was noted for DNMT1 and PRMT3, sigmoidal dose-response curves and reliable estimates of IC 50 values could not be obtained since no significant inhibition was observed at the tested NNMT inhibitor concentrations

Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease

For each eligible study, two authors (MM and AN) independently extracted data, which was then reviewed by a third author (JV) using a piloted spreadsheet, in accordance with Cochrane Collaboration guidelines ( Where relevant data were missing, attempts were made to contact corresponding authors

Cancer-cell metabolism studies NNMT is overexpressed in several cancer cell lines, and 5-Amino-1MQ has been used in vitro to characterise its role in tumour metabolism

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